IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways
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چکیده
منابع مشابه
IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways.
Insulin-like growth factor (IGF)-I and -II have been cloned from a number of teleost species, but their cellular actions in fish are poorly defined. In this study, we show that both IGF-I and -II stimulated zebrafish embryonic cell proliferation and DNA synthesis in a concentration-dependent manner, whereas insulin had little mitogenic activity. Affinity cross-linking and immunoblotting studies...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2001
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.2001.280.4.r1230